Abstract

Introduction

Glecaprevir/pibrentasvir (G/P) is a pan-genotypic direct-acting antiviral therapy approved for use in adults with chronic hepatitis C virus (HCV) infection. This study aimed to assess the real-world efficacy and safety profile of G/P in individuals with chronic HCV.

Materials and Methods

The analysis included patients over 18 years with detectable HCV-RNA who began G/P treatment for chronic HCV between January 1, 2021, and March 1, 2024. The primary outcome measure was sustained virologic response (SVR), defined as undetectable HCVRNA 12 weeks after therapy completion. Safety and tolerability of the regimen were also evaluated.

Results

G/P was administered to 191 patients, of whom 85.5% were male. Among them, 124 patients (64.9%) reported intravenous drug use. The most frequently identified genotype was GT 3 (57.1%). At 12 weeks post-treatment, 105 patients returned for follow-up, and all achieved SVR12. Adverse events occurred in 12 patients (6.3%). One patient discontinued treatment at week 4 due to pruritus and rash.

Conclusion

G/P demonstrates high effectiveness, good tolerability, and a favorable safety profile as a pan-genotypic therapeutic option for chronic HCV infection.