Öz
Biyofilmler ortopedik protez implantları, endotrakeal tüpler, vasküler kateterler, üriner kateterler, doku dolgu implantları gibi araç ilişkili enfeksiyonlara, kronik yara enfeksiyonlarına ve kistik fibrozisli hastalarda kronik akciğer enfeksiyonları gibi enfeksiyonlara neden olabilirler. Biyofilm enfeksiyonlarının tanı ve tedavisi genellikle güçtür. Tanıda biyofilmin yerinde tanımlanmasına yönelik görüntüleme yöntemleri ve biyofilmi oluşturan mikroorganizmanın tanımlanmasına yönelik mikrobiyolojik yöntemler bulunmaktadır. Günümüzde tanı ve tedavisinde yaşanılan güçlükler ve özellikle antibiyotik direnç sorunları gibi problemlere yönelik farklı tedavi yaklaşımları araştırılmaktadır. Çeşitli antibiyotiklerle birlikte fotodinamik tedavi, antibiyotik kilit tedavisi ve çeşitli biyofilm etkili biyoaktif molekül/enzim tedavilerin yakın gelecekte daha yaygın kullanılacağı öngörülmektedir. Bu derlemenin amacı biyofilm ilişkili enfeksiyonların tanı, tedavi ve korunma yöntemlerinin gözden geçirilmesidir.
Anahtar Kelimeler: Ekinokandinler, kronik yara, protez eklem enfeksiyonları, quorum sensing inhibitörleri, antibiyotik kaplı implantlar
Kaynakça
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