Helicobacter pylori ve Faringolaringeal Kanserler Arasındaki İlişki: Gelişimdeki Rolü ve Prognozdaki Önemi

Tuba BAYINDIR; Yaşar BAYINDIR; Çiğdem FIRAT KOCA; İsmail DEMİR; Barış OTLU

doi:10.4274/mjima.galenos.2019.2019.2

Helicobacter pylori ve Faringolaringeal Kanserler Arasındaki İlişki: Gelişimdeki Rolü ve Prognozdaki Önemi

PDF

DERLEME

Helicobacter pylori ve Faringolaringeal Kanserler Arasındaki İlişki: Gelişimdeki Rolü ve Prognozdaki Önemi

Mediterr J Infect Microb Antimicrob 2019;8:2-2 DOI: 10.4274/mjima.galenos.2019.2019.2

, , , ,

PDF

İzin

Öz

Helicobacter pylori dünyada yaygın olarak bulunan ve insanları enfekte eden bir bakteridir. Bu Gram-olumsuz mikroorganizma, mikroaerofilik, spiral ya da eğimli şekildedir ve ayrıca üreaz, katalaz ve oksidaz olumludur. Midedeki asidik ortamda yaşamını sürdürme özelliğine sahiptir. Günümüzde H. pylori’nin gastrik ülser ve malign lezyonlarda rolü olduğu ispatlanmıştır. Dahası, H. pylori’nin kardiyovasküler, dermatolojik, immünolojik, nörolojik, hematolojik, oftalmolojik, jinekolojik, endokrinolojik ve hepatobiliyer hastalıklar gibi çeşitli sistemik hastalıkların nedeni olabileceği bildirilmiştir. Ayrıca literatürde H. pylori enfeksiyonu ile rinit, sinüzit, adenoidit/adenoid hipertrofi, otitis media, tonsillit/tonsil hipertrofisi gibi benign üst solunum yolu hastalıkları arasında olumlu ya da olumsuz ilişki gösteren çok sayıda çalışma bulunmaktadır. Ancak H. pylori’nin patogenezdeki rolü veya bu hastalıklarla olan ilişkisi ile ilgili tartışmalar devam etmektedir. Bununla birlikte bazı çalışmalarda H. pylori’ye karşı oluşan sistemik immün ya da enflamatuvar yanıtın bazı sistemik hastalıkların veya malignitelerin nedeni olabileceği bildirilmiştir. Her ne kadar H. pylori’nin üst ve alt solunum yolu benign ve malign hastalıklarındaki rolü hakkında çalışmalar bulunsa da, H. pylori enfeksiyonu ve solunum yolu hastalıkları arasındaki patofizyolojik ilişkiyi ortaya koymak için daha ileri çalışmalara gereksinim bulunmaktadır. Bu derleme ile literatürde H. pylori ve solunum yollarının hem benign hem de malign hastalıkları arasındaki hem olumlu hem de olumsuz ilişkiyi gösteren çalışmaların özetlenmesi hedeflendi.

Anahtar Kelimeler: Prognostik önem, faringeal karsinom, laringeal karsinom, laringofaringeal reflü, karsinogenez

Kaynakça

1

Lawson AJ. Helicobacter. In: Versalovic J, Carroll KC, Funke G (eds). Manual of Clinical Microbiology. Washington, DC: ASM Press; 2011:900-15.

2

Hagymási K, Tulassay Z. Helicobacter pylori infection: new pathogenetic and clinical aspects. World J Gastroenterol. 2014;20:6386-99.

3

Amizadeh M, Shamsadini A, Arabzadeh A, Jazayeri S. Association of cagA Positive Helicobacter pylori Infection and Laryngeal Squamous Cell Carcinoma: A PCR Approach. Indian J Otolaryngol Head Neck Surg. 2015;67:51-5.

4

Yamaoka Y, Graham DY. Helicobacter pylori virulence and cancer pathogenesis. Future Oncol. 2014;10:1487-500.

5

Dadashzadeh K. Relevance of Helicobacter pylori dupA and oipA genotypes and development of gastric disease. Biomedical Research. 2017;28:8179-83.

6

Malfertheiner P, Malfertheiner P, Megraud F, O’Morain CA, Atherton J, Axon AT, Gensini GF, Gisbert JP, Graham DY, Rokkas T, El-Omar EM, Kuipers EJ. European Helicobacter Study Group. Management of Helicobacter pylori infection-the Maastricht IV/ Florence Consensus Report. Gut. 2012;61:646- 64.

7

Siupsinskiene N, Jurgutaviciute V, Katutiene I, Janciauskas D, Vaitkus S, Adamonis K. Helicobacter pylori infection in laryngeal diseases. Eur Arch Otorhinolaryngol. 2013;270:2283-8.

8

Jabbari MY, Rafeey M, Radfar R. Comparative assessment of Helicobacter pylori colonization in children tonsillar tissues. Int J Pediatr Otorhinolaryngol. 2009;73:1199-2201.

9

Kusano K, Inokuchi A, Fujimoto K, Miyamoto H, Tokunaga O, Kuratomi Y, Shimazu R, Mori D, Yamasaki F, Kidera K, Tsunetomi K, Miyazaki J. Coccoid Helicobacter pylori exists in the palatine tonsils of patients with IgA nephropathy. J Gastroenterol. 2010;45:406-12.

10

Bayindir T, Toplu Y, Otlu B, Yakupogullari Y, Yildirim O, Kalcioglu MT. Prevalence of the Helicobacter pylori in the tonsils and adenoids. Braz J Otorhinolaryngol. 2015;81:307-11.

11

Cirak MY, Ozdek A, Yilmaz D, Bayiz U, Samim E, Turet S. Detection of Helicobacter pylori and its cagA gene in tonsil and adenoid tissues by PCR. Arch Otolaryngol Head Neck Surg. 2003;129:1225-9.

12

Ozyurt M, Gungor A, Ergunay K, Cekin E, Erkul E, Haznedaroglu T. Real-time PCR detection of Helicobacter pylori and virulence-associated cagA in nasal polyps and laryngeal disorders. Otolaryngol Head Neck Surg. 2009;141:131- 5.

13

Ford AC, Axon AT. Epidemiology of Helicobacter pylori infection and public health implications. Helicobacter. 2010;15(Suppl 1):S1-6.

14

Shi Y, Gong H, Zhou L, Tao L, Shi Y, Cao W, Cheng L. Association between Helicobacter pylori infection and laryngeal squamous cell carcinoma in a Chinese male population. ORL J Otorhinolaryngol Relat Spec. 2011;73:295- 300.

15

Cekin E, Ozyurt M, Erkul E, Ergunay K, Cincik H, Kapucu B, Gungor A. The association between Helicobacter pylori and laryngopharyngeal reflux in laryngeal pathologies. Ear Nose Throat J. 2012;91:6-9.

16

Azevedo NF, Guimaraes N, Figueiredo C, Keevil CW, Vieira MJ. A new model for the transmission of Helicobacter pylori: role of environmental reservoirs as gene pools to increase strain diversity. Crit Rev Microbiol. 2007;33:157- 69.

17

Kariya S, Okano M, Nishizaki K. An association between Helicobacter pylori and upper respiratory tract disease: fact or fiction? World J Gastroenterol. 2014;20:1470-84.

18

Hasni SA. Role of Helicobacter pylori infection in autoimmune diseases. Curr Opin Rheumatol. 2012;24:429-34.

19

Tan HJ, Goh KL. Extragastrointestinal manifestations of Helicobacter pylori infection: facts or myth? A critical review. J Dig Dis. 2012;13:342-9.

20

Zhang RG, Duan GC, Fan QT, Chen SY. Role of Helicobacter pylori infection in pathogenesis of gastric carcinoma. World J Gastrointest Pathophysiol. 2016:15;7:97-107.

21

Malfertheiner P, Bornschein J, Selgrad M. Role of Helicobacter pylori infection in gastric cancer pathogenesis: a chance for prevention. J Dig Dis. 2010;11:2-11.

22

Grbesa I, Marinkovic M, Ivkic M, Kruslin B, Novak-Kujundzic R, Pegan B, Bogdanovic O, Bedekovic V, Gall-Troselj K. Loss of imprinting of IGF2 and H19, loss of heterozygosity of IGF2R and CTCF, and Helicobacter pylori infection inlaryngeal squamous cell carcinoma. J Mol Med (Berl). 2008;86:1057-66.

23

Akbayir N, Basak T, Seven H, Sungun A, Erdem L. Investigation of Helicobacter pylori colonization in laryngeal neoplasia. Eur Arch Otorhinolaryngol. 2005;262:170-2.

24

Zhang W, Lu H, Graham DY. An Update on Helicobacter pylori as the Cause of Gastric Cancer. Gastrointest Tumors. 2014;1:155-65.

25

Bitar MA, Soweid A, Mahfouz R, Zaatari G, Fuleihan N. Is Helicobacter pylori really present in the adenoids of children? Eur Arch Otorhinolaryngol. 2005;262:987-92.

26

Mégraud F, Lehours P. Helicobacter pylori detection and antimicrobial susceptibility testing. Clin Microbiol Rev. 2007;20:280-322.

27

Wang YK, Kuo FC, Liu CJ, Wu MC, Shih HY, Wang SS, Wu JY, Kuo CH, Huang YK, Wu DC. Diagnosis of Helicobacter pylori infection: Current options and developments. World J Gastroenterol. 2015;21:11221-35.

28

Masoud N, Manouchehr K, Najmeh D, Monireh H. Lack of association between Helicobacter pylori and laryngeal carcinoma. Asian Pac J Cancer Prev. 2008;9:81-2.

29

Pajic-Penavic I, Danic D, Maslovara S, Gall-Troselj K. Absence of Helicobacter pylori in healthy laryngeal mucosa. J Laryngol Otol. 2010;126:196-9.

30

Yılmaz T, Bajin MD, Günaydın RÖ, Ozer S, Sözen T. Laryngopharyngeal reflux and Helicobacter pylori. World J Gastroenterol. 2014;20:8964-70.

31

Campbell R, Kilty SJ, Hutton B, Bonaparte JP. The Role of Helicobacter pylori in Laryngopharyngeal Reflux. Otolaryngol Head Neck Surg. 2017;156:255- 62.

32

Izadi F, Ahmadi A, Ghourchian S, Daneshi A, Memari F, Khadivi E, Mohammadi S. Detection of Helicobacter pylori in benign laryngeal lesions by polymerase chain reaction: a cross sectional study. Infect Agent Cancer. 2012;19:7-10.

33

de Martel C, Franceschi S. Infections and cancer: established associations and new hypotheses. Crit Rev Oncol Hematol. 2009;70:183-94.

34

Zhou J, Zhang D, Yang Y, Zhou L, Tao L. Association between Helicobacter pylori infection and carcinoma of the larynx or pharynx. Head Neck. 2016;38:E2291-6.

35

Rezaii J, Tavakoli H, Esfandiari K, Ashegh H, Hasibi M, Ghanei G, Khosh- Batn M, Rashidi A. Association between Helicobacter pylori infection and laryngo-hypopharyngeal carcinoma: a case-control study and review of the literature. Head Neck. 2008;30:1624-7.

36

Aygenc E, Selcuk A, Celikkanat S, Ozbek C, Ozdem C. The role of Helicobacter pylori infection in the cause of squamous cell carcinoma of the larynx. Otolaryngol Head Neck Surg. 2001;125:520-1.

37

Kizilay A, Saydam L, Aydin A, Kalcioglu MT, Ozturan O, Aydin NE. Histopathologic examination for Helicobacter pylori as a possible etiopathogenic factor in laryngeal carcinoma. Chemotherapy. 2006;52:80- 2.

38

Rubin JS, Benjamin E, Prior A, Lavy J. The prevalence of Helicobacter pylori infection in malignant and premalignant conditions of the head and neck. J Laryngol Otol. 2003;117:118-21.

39

Burduk PK. Association between infection of virulence cagA gene Helicobacter pylori and laryngeal squamous cell carcinoma. Med Sci Monit. 2013;19:584-91.

40

Gong H, Shi Y, Zhou L, Tao L, Shi Y, Cao W, Cheng L. Helicobacter pylori infection of the larynx may be an emerging risk factor for laryngeal squamous cell carcinoma. Clin Transl Oncol. 2012;14:905-10.

41

Titiz A, Ozcakir O, Ceyhan S, Yilmaz YF, Unal A, Akyon Y. The presence of Helicobacter pylori in the larynx pathologies. Auris Nasus Larynx. 2008;35:534-8.

42

Genc R, Çağlı S, Yüce İ, Vural A, Okuducu H, Patıroğlu T, Güney E. The role of H. pylori in the development of laryngeal squamous cell carcinoma. Dis Markers. 2013;35:447-9.

43

Yilmaz I, Erkul E, Berber U, Kucukodaci Z, Narli G, Haholu A, Demirel D. The presence of Helicobacter pylori in laryngeal squamous cell carcinoma. Eur Arch Otorhinolaryngol. 2016;273:761-5.

44

Pirzadeh A, Doustmohammadian N, Khoshbaten M, Doustmohammadion S. Is there any association between Helicobacter pylori infection and laryngeal carcinoma? Asian Pac J Cancer Prev. 2011;12:897-900.

45

Momtaz H, Souod N, Dabiri H, Sarshar M. Study of Helicobacter pylori genotype status in saliva, dental plaques, stool and gastric biopsy samples. World J Gastroenterol. 2012;18:2105-11.

46

Tas DA, Yakar T, Sakalli H, Serin E. Impact of Helicobacter pylori on the clinical course of recurrent aphthous stomatitis. J Oral Pathol Med. 2013;42:89-94.

47

Olivier BJ, Bond RP, van Zyl WB, Delport M, Slavik T, Ziady C, Terhaar Sive Droste JS, Lastovica A, van der Merwe SW. Absence of Helicobacter pylori within the oral cavities of members of a healthy South African community. J Clin Microbiol. 2006;44:635-6.

48

Kignel S, de Almeida Pina F, Andre EA, Alves Mayer MP, Birman EG. Occurrence of Helicobacter pylori in dental plaque and saliva of dyspeptic patients. Oral Dis. 2005;11:17-21.

49

Grimm M. Immunohistochemical detection of Helicobacter pylori without association of TLR5 expression in oral squamous cell carcinoma. J Oral Pathol Med. 2014;43:35-44.

50

Zhang JP, Peng ZH, Zhang J, Zhang XH, Zheng QY. Helicobacter pylori infection in the pharynx of patients with chronic pharyngitis detected with TDI-FP and modified Giemsa stain. World J Gastroenterol. 2006;12:468-72.

51

Dayama A, Srivastava V, Shukla M, Singh R, Pandey M. Helicobacter pylori and oral cancer: possible association in a preliminary case control study. Asian Pac J Cancer Prev. 2011;12:1333-6.

52

Okuda K, Ishihara K, Miura T, Katakura A, Noma H, Ebihara Y. Helicobacter pylori may have only a transient presence in the oral cavity and on the surface of oral cancer. Microbiol Immunol. 2000;44:385-8.

53

Nurgalieva ZZ, Graham DY, Dahlstrom KR, Wei Q, Sturgis EM. A pilot study of Helicobacter pylori infection and risk of laryngopharyngeal cancer. Head Neck. 2005;27:22-7.

54

Grandis JR, Perez-Perez GI, Yu VL, Johnson JT, Blaser MJ. Lack of serologic evidence for Helicobacter pylori infection in head and neck cancer. Head Neck. 1997;19:216-8.

55

Guilemany JM, Langdon C, Ballesteros F, Blanch JL. Prognostic significance and association of Helicobacter pylori infection in pharyngolaryngeal cancer. Eur Arch Otorhinolaryngol. 2014;271:2539-43.