Öz
Progresif multifokal lökoensefalopati (PML), merkezi sinir sisteminde (MSS) miyelin üreten hücreler olan oligodentrositlerin John Cunningham virüsü litik enfeksiyonu sonucu gelişen MSS’nin demiyelinizan bir hastalığıdır. Semptomlar lezyonların yeri ve büyüklüğüne bağlı olarak büyük ölçüde değişiklik gösterir ve en sık görülen klinik tablo motor bozukluklar, bilinç bozukluğu, ataksi ve görme semptomları ile karakterizedir. Başvuruda en sık karşılaşılan semptom ekstremitelerde güçsüzlük veya hemiparezi iken istemsiz hareketler çok daha nadir görülmektedir ve literatürde ek nörolojik hastalık olmaksızın fokal hareket bozukluğu görülen az sayıda olgu bildirilmiştir. Bu yazıda, üst ekstremitelerin bilateral miyoklonusu ile başvuran, non-Hodgkin lenfoma için immünmodülatör kemoterapiler ile tedavi edilmekte olan bir PML olgusu sunulmaktadır. Bu olgu sunumu, fokal hareket bozukluklarının ayırıcı tanısında PML’nin dikkate alınmasının önemini vurgulamakta ve bu atipik olguların potansiyel nedensel mekanizmasını tartışmaktadır.
Anahtar Kelimeler: Progresif multifokal lökoensefalopati, hareket bozukluğu, immünosüpresyon, manyetik rezonans görüntüleme
Kaynakça
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