Öz
Acinetobacter baumannii (A. baumannii), hastane salgınlarının çoğuyla ilişkili Gram-olumsuz fırsatçı ve nozokomiyal bir patojendir. Bu patojenin başarısı, stresli hastane koşullarında (kuruma, besin yokluğu ve antimikrobiyal tedaviler) hayatta kalma kabiliyetine doğrudan bağlanabilir. Bu hayatta kalma yeteneği, A. baumannii’nin cansız (polistiren ve cam) ve canlı yüzeylerde (epitel hücreleri ve mantar filamentleri) biyofilmler oluşturma yeteneğinden kaynaklanmaktadır. Bu derlemenin amacı; özellikle biyofilm-ilişkili protein, CsuA/BABCD şaperon-kılavuz pili sistemi, poli-β-1,6-N-asetilglukozamin, dış membran proteini A, çoğunluk algılanması, yüzey özellikleri ve büyüme koşulları gibi A. baumannii’nin biyofilm oluşumunda rol oynayan farklı faktörleri bildirmektir. Bu derlemede ayrıca, A. baumannii biyofilminin önlenmesi ve tedavisinde yararlı olabilecek çeşitli stratejilere ek olarak, biyofilm oluşumu ve çoklu ilaç direnci arasındaki ilişki tartışılacaktır.
Anahtar Kelimeler: Acinetobacter baumannii, biyofilm, genetik belirleyiciler, antibiyotik direnci, tedavi stratejileri
Kaynakça
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