Öz
Giriş: Bu çalışmada serum 25(OH) vitamin D [25(OH)D] düzeyleri ile Koronavirüs hastalığı-2019’un (COVID-19) klinik seyri arasındaki ilişkinin değerlendirilmesi amaçlanmıştır.
Gereç ve Yöntem: Bu tek merkezli, ileriye dönük çalışmada, COVID-19 hastaları komplikasyonsuz hastalık, hafif pnömoni ve şiddetli pnömoni olarak üç gruba ayrılmıştır. Bu olgular, klinik ve laboratuvar bulguları ile hastaneye yatıştaki serum 25(OH)D düzeyleri açısından karşılaştırılmıştır. Ayrıca hastalar yoğun bakım destek gereksinimi ve mortalite gelişimi açısından gruplandırılmış ve 25(OH)D vitamini düzeyleri açısından karşılaştırılmıştır.
Bulgular: COVID-19 ve kontrol gruplarının medyan serum 25(OH)D düzeyleri 16 (11-23) sırasıyla ng/ml ve 21,5 (18-25) ng/ml (p<0,001) olarak saptanmıştır. Komplike olmayan, hafif pnömoni ve şiddetli pnömoni gruplarında 25(OH)D düzeyleri sırasıyla 16,5 ng/ml (16 ila 25,2), 15 (11 ila 21) ve 16 ng/ml (11,5 ila 26,5) olarak saptanmış ve gruplar arasında istatistiksel anlamlı farklılık saptanmamıştır (p=0,521). COVID-19 ile ilgili sonuçlar açısından karşılaştırıldığında, D vitamini düzeylerinde anlamlı bir fark saptanmamıştır (p=0,411, p=0,438).
Sonuç: D vitamini eksikliği olan hastalar, COVID-19 enfeksiyonları açısından daha yüksek riske sahip olabilirler. Bununla birlikte, serum D vitamini seviyeleri ile COVID-19’un klinik şiddeti ve sonucu arasında bir ilişki gösterilememiştir.
Anahtar Kelimeler: COVID-19, D vitamini eksikliği, klinik önem, sonuçlar
Kaynakça
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