Öz
Mastit, genellikle 18-50 yaşlarındaki kadın hastalarda görülen meme dokusunun yaygın selülit durumudur. Nadir tiplerinden biri olan granülomatöz mastit (GM) ise genellikle idiyopatik bir hastalık olup, enfeksiyöz nedenlerle de oluşabilir. Bu olgu raporunda Corynebacterium amycolatum ile enfekte GM tanısı almış 35 yaşında kadın hasta bildirilmiş ve ilgili literatür bilgileri gözden geçirilmiştir. Hasta amoksisilin/klavulanik asit ve klindamisin kombinasyonu ile tedavi edilmiş, hastanın 10 aylık takibinde nüks saptanmamıştır.
Anahtar Kelimeler: Corynebacterium, Corynebacterium amycolatum, mastit, granülomatöz mastit, MALDI-TOF MS
Kaynakça
Kessler E, Wolloch Y. Granulomatous mastitis: a lesion clinically simulating carcinoma. Am J Clin Pathol. 1972;58:642-6.
Barreto DS, Sedgwick EL, Nagi CS, Benveniste AP. Granulomatous mastitis: etiology, imaging, pathology, treatment, and clinical findings. Breast Cancer Res Treat. 2018;171:527-34.
Bakaris S, Yuksel M, Ciragil P, Guven MA, Ezberci F, Bulbuloglu E. Granulomatous mastitis including breast tuberculosis and idiopathic lobular granulomatous mastitis. Can J Surg. 2006;49:427-30.
Dobinson HC, Anderson TP, Chambers ST, Doogue MP, Seaward L, Werno AM. Antimicrobial Treatment Options for Granulomatous Mastitis Caused by Corynebacterium Species. J Clin Microbiol. 2015;53:2895-9.
Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing. 27th ed. CLSI supplement M100. Wayne, PA: Clinical and Laboratory Standards Institute; 2017.
Reddy BS, Chaudhury A, Kalawat U, Jayaprada R, Reddy G, Ramana BV. Isolation, speciation, and antibiogram of clinically relevant non-diphtherial Corynebacteria (Diphtheroids). Indian J Med Microbiol. 2012;30:52-7.
Soltan Mohammadi N, Mafakheri S, Abdali N, Barcena-Uribarri I, Tauch A, Benz R. Identification and characterization of the channel-forming protein in the cell wall of Corynebacterium amycolatum. Biochim Biophys Acta. 2013;1828:2574-82.
Kazmierczak AK, Szarapinska-Kwaszewska JK, Szewczyk EM. Opportunistic coryneform organisms--residents of human skin. Pol J Microbiol. 2005;54:27-35.
Butta H, Pasha F, Dawar R, Kashyap V, Mendiratta L, Bora U, Sardana R. Corynebacterium amycolatum causing breast abscess: An infecting Diphtheroid with a difference. Ann Pathol Lab Med. 2017;4:C128-30.
Ozaydin I, Yildirim M, Sahin I, Dogan S. Recurrent breast abscess caused by Corynebacterium amycolatum: A case report. Turk J Med Sci. 2009;39:147-9.
Paviour S, Musaad S, Roberts S, Taylor G, Taylor S, Shore K, Lang S, Holland D. Corynebacterium species isolated from patients with mastitis. Clin Infect Dis. 2002;35:1434-40.
Poojary I, Kurian A, V AJ, Devapriya JD, M AT. Corynebacterium species causing breast abscesses among patients attending a tertiary care hospital in Chennai, South India. Infect Dis (Lond). 2017;49:528-31.
Neemuchwala A, Soares D, Ravirajan V, Marchand-Austin A, Kus JV, Patel SN. In Vitro Antibiotic Susceptibility Pattern of Non-diphtheriae Corynebacterium Isolates in Ontario, Canada, from 2011 to 2016. Antimicrob Agents Chemother. 2018;62:e01776-17.
Zalas P, Mikucka A, Gospodarek E. [Antibiotic sensitivity of Corynebacterium amycolatum]. Med Dosw Mikrobiol. 2004;56:327-34.
Bao R, Gao X, Hu B, Zhou Z. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry: a powerful tool for identification of Corynebacterium species. J Thorac Dis. 2017;9:3239-45.
Alibi S, Ferjani A, Gaillot O, Marzouk M, Courcol R, Boukadida J. Identification of clinically relevant Corynebacterium strains by Api Coryne, MALDI-TOF-mass spectrometry and molecular approaches. Pathol Biol (Paris). 2015;63:153-7.
Ang LM, Brown H. Corynebacterium accolens isolated from breast abscess: possible association with granulomatous mastitis. J Clin Microbiol. 2007;45:1666-8.
Taylor GB, Paviour SD, Musaad S, Jones WO, Holland DJ. A clinicopathological review of 34 cases of inflammatory breast disease showing an association between Corynebacteria infection and granulomatous mastitis. Pathology. 2003;35:109-19.


