Antibiyotiğe Dirençli Bakterileri Yeniden Duyarlılaştırmak için Kullanılan Bileşikler ve Yöntemler

Priya SWAMINATHAN; Suravi SEN; Mandira M.A.; Abhirami A. PRASAD

doi:10.4274/mjima.galenos.2021.2021.46

Antibiyotiğe Dirençli Bakterileri Yeniden Duyarlılaştırmak için Kullanılan Bileşikler ve Yöntemler

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Antibiyotiğe Dirençli Bakterileri Yeniden Duyarlılaştırmak için Kullanılan Bileşikler ve Yöntemler

Mediterr J Infect Microb Antimicrob 2021;10:46-46 DOI: 10.4274/mjima.galenos.2021.2021.46

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İzin

Öz

Bakterilerin antibiyotiklerin bakteriyostatik ve bakterisidal özelliklerine karşı direnci, farklı tipte antibiyotiklerin kullanımını kısıtlayan önemli bir sağlık sorunudur. Potansiyel bir alternatif, enfeksiyonlara karşı mevcut antibiyotiklerle işbirliği içinde hareket eden direnci değiştiren kimyasallar, terapiler veya bileşikler kullanarak çoklu ilaca dirençli bakterileri yeniden duyarlı hale getirmektir. Bu nedenle, 2AI bileşikleri, belirli bitki özleri ve diğer kimyasallar gibi çeşitli bileşiklerin duyarlılığı indüklemedeki rollerini anlamak için bu tip bileşikler üzerinde tartışmak istedik. Ana bileşenlerden biri olan H₂S’nin sitotoksik olduğu bilinmektedir ve H₂S bakteriler üzerinde çeşitli etkiler göstermektedir. Endojen H₂S, çeşitli bakteri türlerine karşı direnç sağlar. Bu arada, devam eden bir araştırma, eksojen H₂S’nin bakterilerde duyarlılığı nasıl indükleyebileceğini araştırmaktadır. Bu nedenle gelecekte bakteriyel hastalıklarla savaşmak için mevcut antibiyotiklerde ve tedavilerde alternatiflere veya gelişmelere ihtiyaç duyulacaktır.

Anahtar Kelimeler: Antibiyotik direnci, antibiyotikler, bakteriyel duyarlılık, kombine tedavi

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