Öz
Herpes simpleks virüs tip-1 (HSV-1), ağız ve yüz lezyonlarından ölümcül ensefalite ve herpetik keratite kadar çeşitli sonuçlara neden olan yaygın bir patojendir. Asiklovir (ACV), HSV-1 enfeksiyonunun tedavisinde güncel bir seçenektir. Bununla birlikte, ACV-dirençli HSV-1’in ortaya çıkışı ve akut böbrek hasarı gibi uzun süreli ACV uygulamasının zararlı yan etkileri göz önüne alındığında, yeni antiviral terapötik ajanların ve yeni ilaç dağıtım sistemlerinin geliştirilmesi vazgeçilmez görünmektedir. Nanoteknolojinin gelişmesiyle birlikte nanopartiküller (NP), benzersiz fiziksel ve kimyasal özelliklerinden dolayı antimikrobiyal ajanlar ve ilaç taşıyıcıları olarak büyük ilgi görmüştür. Bu derlemede, NP’lerin HSV-1’e karşı antiviral aktivitesine ve bunların ACV dağıtımındaki uygulamalarına odaklandık.
Anahtar Kelimeler: Antiviral tedavi, HSV-1 enfeksiyonu, nanopartiküller, nanotaşıyıcılar, asiklovir
Kaynakça
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