Öz
Giriş: Koronavirüs hastalığı-2019 (COVID-19) hastalarında tanı aşamasında orofarenks/nazofarenks sürüntüsünden hesaplanan viral yük ile laboratuvar parametreleri ve radyolojik bulgular arasındaki ilişkinin araştırılması amaçlandı.
Gereç ve Yöntem: Malatya Turgut Özal Üniversitesi Hastanesi’ne başvuran orofarenks/nazofarenks sürüntüde revers transkriptaz-polimeraz zincir reaksiyonu (qPCR) ile ciddi akut solunum yolu sendromu-koronavirüs-2 pozitif saptanan 67 hasta çalışmaya dahil edildi. Hastalara ait demografik veriler, laboratuvar parametreleri ve toraks bilgisayarlı tomografi bulguları kaydedildi. Viral yük ile bu veriler arasındaki ilişki karşılaştırıldı.
Bulgular: Hastaların yaş ortalaması 63,4±9,8, ortalama vücut kitle indeksi (VKİ) 28,6±5,4, ortalama döngü eşik değeri (Ct) 21,4±5,2 idi. Ct değeri ile cinsiyet, yaş ve VKİ arasında ilişki bulunamadı. Radyolojik bulguların şiddeti ile Ct değeri, yaş ve cinsiyet arasında istatistiksel olarak anlamlı bir ilişki vardı. Ct değeri ile laboratuvar parametreleri olan C-reaktif protein, lökosit, nötrofil, lenfosit, nötrofil-lenfosit oranı, ferritin, albümin ve kalsiyum düzeyleri arasında istatistiksel olarak anlamlı bir ilişki vardı. Hemoglobin, hematokrit, trombosit, üre, kreatinin, total protein, gama glutamil transferaz, alkalen fosfataz, sodyum, potasyum, D-dimer, prokalsitonin düzeyleri ve Ct değeri arasında ise istatistiksel olarak anlamlı bir ilişki bulunmadı.
Sonuç: Sonuç olarak PCR ile erken dönemde gösterilen viral yük miktarı, hastanın akciğerlerinin ileri immünolojik fazda ne kadar kötü olabileceğini öngörmektedir. Ct değeri, hastaların radyolojik ve biyokimyasal durumunu değerlendirmek için bağımsız bir faktör olarak kullanılabilir.
Anahtar Kelimeler: SARS-CoV-2, viral yük, lenfopeni
Kaynakça
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