Öz
Giriş
Yapılan çalışmanın amacı, maternal insan immün yetmezlik virüsü (HIV), Hepatit B ve Hepatit C enfeksiyonlarında perinatal bulaş riski ve prevalansını bibliyometrik analiz yöntemiyle incelemektir.
Gereç ve Yöntem
Çalışmada, anahtar kelimeler kullanılarak 1982-2025 yılları arasında yayımlanan tüm makaleler taranmıştır. Yalnızca 1982 sonrası yayımlanmış, İngilizce dilinde yazılmış orijinal araştırmalar dahil edilmiştir. Toplam 1,058 kayıt saptanmış, bunların 1,016’sı İngilizce yayınlardan oluşmuştur. Veriler dışa aktarılmış ve Mendeley programı kullanılarak tekrarlayan kayıtlar çıkarılmıştır. Nicel analizler ve görselleştirmeler Microsoft Excel, VOSviewer ve Bibliometrix (R Studio) yazılımları kullanılarak gerçekleştirilmiştir. Nihai analiz 1,015 makale üzerinden yapılmıştır.
Bulgular
Amerika Birleşik Devletleri 457 makale (%44,98) ile en üretken ülke olarak belirlenmiştir. En üretken yazar 32 makale ile Newell’dır. En çok atıf alan çalışma ise “Combination antiretroviral strategies for the treatment of pregnant HIV-1-infected women and prevention of perinatal HIV-1 transmission” başlıklı makale olup 738 atıf almıştır. Ayrıca, son otuz yılda maternal HIV, Hepatit B ve Hepatit C enfeksiyonlarında perinatal bulaş riski ve prevalansını ele alan araştırma eğilimlerinde belirgin bir artış gözlenmiştir.
Sonuç
Bu alandaki çalışmaların sayısındaki artış, konunun uluslararası ölçekte daha fazla ilgi gördüğünü ve araştırma kapsamının genişlediğini göstermektedir. Ayrıca, son otuz yılda maternal HIV, Hepatit B ve Hepatit C enfeksiyonlarında perinatal bulaş riski ve prevalansını inceleyen çalışmalarda belirgin bir artış gözlenmiştir.
Anahtar Kelimeler: Maternal HIV, maternal Hepatit B, maternal Hepatit C, perinatal bulaş, vertikal bulaş
Kaynakça
Clement ME, Kofron R, Landovitz RJ. Long-acting injectable cabotegravir for the prevention of HIV infection. Curr Opin HIV AIDS. 2000;15(1):19-26.
Ott JJ, Stevens GA, Groeger J, Wiersma ST. Global epidemiology of Hepatitis B virus infection: New estimates of age-specific HBsAg seroprevalence and endemicity. Vaccine. 2012;30(12):2212-9.
Quek JWE, Loo JH, Lim EQ, Chung AH, Othman ABB, Tan JJ, Barnett S, Nguyen MH, Wong YJ. Global epidemiology, natural history, maternal-to-child transmission, and treatment with DAA of pregnant women with HCV: A systematic review and meta-analysis. EClinicalMedicine. 2024;74:102727.
World Health Organization (WHO). Global progress report on HIV, viral hepatitis and sexually transmitted infections, 2021: accountability for the global health sector strategies 2016-2021-actions for impact. Geneva: WHO; 2021. Available from: https://www.who.int/publications/i/item/9789240027077
Vollset SE, Gissler M, Håberg SE, Magnus MC, Haug K, Brantsæter AL, Haugen M, Meltzer HM, Grjibovski AM, Magnus P. Global burden of maternal and child health interventions: a bibliometric analysis. Lancet. 2024;404(10353):1234-45.
Aria M, Cuccurullo C. Bibliometrix: an R-tool for comprehensive science mapping analysis. J Informetrics. 2017;11(4):959-75.
van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics. 2010;84(2):523-38.
van Eck NJ, Waltman L. Citation-based clustering of publications using CitNetExplorer and VOSviewer. Scientometrics. 2017;111(2):1053-70.
Newell ML. Prevention of mother-to-child transmission of HIV: Challenges for the next decade. Am J Public Health. 2006;96(8):1383-7.
Fowler MG, Qin M, Fiscus SA, Currier JS, Flynn PM, Tomlinson MJ, Smeriglio V, Cunningham CK, Mofenson LM, Rogers M, Coovadia HM, Thorne C, McIntyre JA, Rich K, Lockman S, Ribaudo HJ, Persaud D. Prevention of mother-to-child transmission of HIV-1 in resource-limited settings. J Infect Dis. 2007;195(Suppl 3):S119-24.
Myer L, Denny L, Wright TC, Kuhn L, Stein ZA. Mother-to-child transmission of HIV in sub-Saharan Africa: Challenges and progress. Clin Perinatol. 2010;37(4):699-19.
Abrams EJ, Stringer JS, Weidle PJ, Ekouevi DK, Ouedraogo S, Mwanyumba F, Myer L, Tejiokem MC, Coovadia HM, Rollins N, Mofenson LM. HIV transmission and maternal health: optimizing maternal antiretroviral therapy. Curr Opin HIV AIDS. 2007;2(6):448-53.
Resti M, Pinter A, Villani A, Massironi E, Zecca M, Giaquinto C. Mother-to-child transmission of Hepatitis C virus. Acta Paediatr. 2002;91(7):705-9.
Cooper ER, Charurat M, Mofenson L, Hanson IC, Pitt J, Diaz C, Hayani K, Handelsman E, Smeriglio V, Hoff R, Blattner W; Women and Infants’ Transmission Study Group. Combination antiretroviral strategies for the treatment of pregnant HIV-1-infected women and prevention of perinatal HIV-1 transmission. J Acquir Immune Defic Syndr. 1999;29(5):484-4.
Blanche S, Rouzioux C, Moscato ML, Veber F, Mayaux MJ, Jacomet C, Tricoire J, Deville A, Vial M, Firtion G; HIV Infection in Newborns French Collaborative Study Group. A prospective study of infants born to women seropositive for human immunodeficiency virus type 1. N Engl J Med. 1989;320(25):1643-8.
Townsend CL, Cortina-Borja M, Peckham CS, de Ruiter A, Lyall H, Tookey PA. Low rates of mother-to-child transmission of HIV following effective pregnancy interventions in the United Kingdom and Ireland, 2000-2006. AIDS. 2008;22(8):973-81.
Giaquinto C, Tovo PA, Caronna C, De Rossi A, Gabiano C, Faldella G. Mother-to-child transmission of HIV in Europe. Clin Infect Dis. 2005;40(3):458-65.
Coutsoudis A, Pillay K, Spooner E, Kuhn L, Coovadia HM. Influence of infant-feeding patterns on early mother-to-child transmission of HIV-1 in Durban, South Africa: a prospective cohort study. J Infect Dis. 2001;183(1):146-52.
Landesman SH, Kalish LA, Burns DN, Minkoff H, Fox HE, Zorrilla C, Garcia P, Fowler MG, Mofenson L, Tuomala RE. Obstetrical factors and the transmission of human immunodeficiency virus type 1 from mother to child. N Engl J Med. 1996;334(25):1617-23.
Fideli US, Allen SA, Musonda R, Trask S, Hahn BH, Weiss H, Mulenga J, Kasolo F, Vermund SH, Aldrovandi GM. Virologic and immunologic determinants of heterosexual transmission of human immunodeficiency virus type 1 in Africa. AIDS Res Hum Retroviruses. 2001;17(10):901-10.
Wiseman E, Fraser MA, Holden S, Glass A, Kidson BL, Heron LG, Maley MW, Ayres A, Locarnini SA, Levy MT. Perinatal transmission of Hepatitis B virus: an Australian experience. Med J Aust. 2009;190(9):489-92.
Zou H, Chen Y, Duan Z, Zhang H, Pan C. Virologic factors associated with failure to passive-active immunoprophylaxis in infants born to HBsAg-positive mothers. J Viral Hepat. 2012;19(2):e18-25.
Tuomala RE, Shapiro DE, Mofenson LM, Bryson Y, Culnane M, Hughes MD, O’Sullivan MJ, Scott G, Stek AM, Wara D, Bulterys M. Antiretroviral therapy during pregnancy and the risk of an adverse outcome. N Engl J Med. 2002;346(24):1863-70.
Mehrabi F, Karamouzian M, Farhoudi B, Moradi Falah Langeroodi S, Mehmandoost S, Abbaszadeh S, Motaghi S, Mirzazadeh A, Sadeghirad B, Sharifi H. Comparison of safety and effectiveness of antiretroviral therapy regimens among pregnant women living with HIV: a systematic review and network meta-analysis of randomized trials. BMC Infect Dis. 2024;24:417.
Joint United Nations Programme on HIV/AIDS (UNAIDS). Global AIDS update 2023: the path that ends AIDS. Joint United Nations Programme on HIV/AIDS; 2023. Available from: https://www.unaids.org/en/resources/documents/2023/global-aids-update-2023
Dobritoiu R, Pacurar D, Vlad RM, Plesca DA. Vertical transmission of hepatitis B and C—Then and now—A comprehensive literature systematic review. Viruses. 2025;17(10):1395.
World Health Organization (WHO). Guidelines for the prevention, diagnosis, care and treatment for people with chronic hepatitis B infection: policy brief. World Health Organization; 2024. Available from: https://www.who.int/publications/i/item/9789240090903
